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Publications

Research articles: 1992 - present

 

 
 

Cote ,R.H. (2006). Photoreceptor phosphodiesterase (PDE6): a G-protein-activated PDE regulating visual excitation in rod and cone photoreceptor cells. In Cyclic Nucleotide Phosphodiesterases in Health and Disease, J.A.Beavo, S.H.Francis, and M.D.Houslay, eds. ( Boca Raton , FL : CRC Press), pp. 165-193.

Pentia,D., Hosier,S., and Cote,R.H. (2006). The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. J Biol. Chem. 281: 5500-5505

Zhang,X., Feng,Q., and Cote,R.H. (2005). Efficacy and selectivity of phosphodiesterase-targeted drugs in inhibiting photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors. Invest. Ophthalmol. Vis. Sci. 46 , 3060-3066.

Zhang,H., Hosier,S., Terew,J.M., Zhang,K., Cote ,R.H., and Baehr,W. (2005). Assay and functional properties of PrBP (PDEd), a prenyl binding protein interacting with multiple partners. Methods Enzymol. 403: 42-56

Cote,R.H. (2005). cGMP binding to the regulatory GAF domains of photoreceptor phosphodiesterase (PDE6). Methods in Molecular Biology 307 , 141-154.

Pentia,D.C., Hosier,S., Collupy,R.A., Valeriani,B.A., and Cote,R.H. (2005). Purification of PDE6 isozymes from mammalian retina. Methods in Molecular Biology 307: 125-140.

Carleton,K.L., Spady,T.C., and Cote,R.H. (2005). Rod and cone opsin families differ in spectral tuning domains but not signal transducing domains as judged by saturated evolutionary trace analysis. J. Mol. Evol. 61: 75-89

Zhang, X. and Cote, R.H. (2005) cGMP signaling in vertebrate retinal photoreceptor cells. Front. Bioscience 10:1191-1204

Norton AW, Hosier S, Terew JM, Li N, Dhingra A, Vardi N, Baehr W, Cote RH. (2005)
Evaluation of the 17 kDa prenyl binding protein as a regulatory protein for phototransduction in retinal photoreceptors. J Biol Chem. 280: 1248-1256

Cote , R.H. (2004) Characteristics of Photoreceptor PDE (PDE6): similarities and differences to PDE5. Intl. J. Impotence Res. 16, S28-S33

  Corbin, J. D., Kotera, J., Gopal, V. K., Cote, R. H., and Francis, S. H. (2003). Regulation of cyclic nucleotide levels by sequestration. In Handbook of Cell Signaling, R. Bradshaw and E. Dennis, eds. (San Diego: Academic Press), pp. 453-457.
  Cote, R. H. (2003). Structure, function, and regulation of photoreceptor phosphodiesterase (PDE6). In Handbook of Cell Signaling, R. A. Bradshaw and E. A. Dennis, eds. (San Diego: Academic Press), pp. 453-458.
Paglia, M. J., Mou, H., and Cote, R. H. (2002). Regulation of photoreceptor phosphodiesterase (PDE6) by phosphorylation of its inhibitory γ subunit re-evaluated. J. Biol. Chem. 277, 5017-5023.
Kameni Tcheudji, J. F., Lebeau, L., Virmaux, N., Maftei, C. G., Cote, R. H., Lugnier, C., and Schultz, P. (2001). Molecular organization of bovine rod cGMP-phosphodiesterase 6. J. Mol. Biol. 310, 781-791.
Mou, H. and Cote, R. H. (2001). The catalytic and GAF domains of the rod cGMP phosphodiesterase (PDE6) heterodimer are regulated by distinct regions of its inhibitory γ subunit. J. Biol. Chem. 276, 27527-27534.
Cote, R. H. (2000). Kinetics and regulation of cGMP binding to noncatalytic binding sites on photoreceptor phosphodiesterase. Methods Enzymol. 315, 646-672.
Norton, A. W., D'Amours, M. R., Grazio, H. J., Hebert, T. L., and Cote, R. H. (2000). Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase: allosteric interactions between the inhibitory γ subunit and the noncatalytic cGMP binding sites. J. Biol. Chem. 275, 38611-38619.
D'Amours, M. R. and Cote, R. H. (1999). Regulation of photoreceptor phosphodiesterase catalysis by its noncatalytic cGMP binding sites. Biochem. J. 340, 863-869.
D'Amours, M. R., Granovsky, A. E., Artemyev, N. O., and Cote, R. H. (1999). The potency and mechanism of action of E4021, a PDE5-selective inhibitor, on the photoreceptor phosphodiesterase depends on its state of activation. Mol. Pharmacol. 55, 508-514.
Mou, H., Grazio, H. J., Cook, T. A., Beavo, J. A., and Cote, R. H. (1999). cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its γ and δ subunits. J. Biol. Chem. 274, 18813-18820.
Artemyev, N. O., Arshavsky, V. Y., and Cote, R. H. (1998). Photoreceptor phosphodiesterase: Interaction of inhibitory γ subunit and cyclic GMP with specific binding sites on catalytic subunits. Methods 14, 93-104.

Hebert, M. C., Schwede, F., Jastorff, B., and Cote, R. H. (1998). Structural features of the noncatalytic cGMP binding sites of frog photoreceptor phosphodiesterase using cGMP analogs. J. Biol. Chem. 273, 5557-5565.
Coccia, V. J. and Cote, R. H. (1994). Regulation of intracellular cyclic GMP concentration by light and calcium in electropermeabilized rod photoreceptors. J. Gen. Physiol. 103, 67-86.
Cote, R. H., Bownds, M.D., and Arshavsky, V. Y. (1994). cGMP binding sites on photoreceptor phosphodiesterase: Role in feedback regulation of visual transduction. Proc. Natl. Acad. Sci. U.S.A. 91, 4845-4849.
Cote, R. H. and Brunnock, M. A. (1993). Intracellular cGMP concentration in rod photoreceptors is regulated by binding to high and moderate affinity cGMP binding sites. J. Biol. Chem. 268, 17190-17198.
Forget, R. S., Martin, J. E., and Cote, R. H. (1993). A centrifugal separation procedure detects moderate affinity cGMP binding sites in membrane-associated proteins and permeabilized cells. Anal. Biochem. 215, 159-161.
  Lisman, J. E., Erickson, M., Richard, E. A., Cote, R. H., Bacigalupo, J., Johnson, E. C., and Kirkwood, A. (1992). Mechanisms of amplification, deactivation and noise reduction in invertebrate photoreceptors. In Sensory Transduction, D. P. Corey and S. D. Roper, eds. (New York: Rockefeller Press), pp. 176-199.
Research Articles: 1974 - 1991